Article

Transcription imparts architecture, function, and logic to enhancer units

2019-11-07

Abstract excerpt

Distal enhancers remain one of the least understood regulatory elements with pivotal roles in development and disease. We used massively parallel reporter assays to perform functional comparisons of two leading enhancer models and find that gene-distal transcription start sites (TSSs) are robust predictors of enhancer activity with higher resolution and specificity than histone modifications. We show that active e...

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Literature Corpus work: 5d3bbd09-d9fb-5ed5-bad9-eddcb0e9d495
DOI: 10.1101/818849

Open publication

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