Article
Systematic dissection of genomic features determining transcription factor binding and enhancer function.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017
Grossman Sharon R, Zhang Xiaolan, Wang Li, Engreitz Jesse, Melnikov Alexandre, Rogov Peter, Tewhey Ryan, Isakova Alina, Deplancke Bart, Bernstein Bradley E, Mikkelsen Tarjei S, Lander Eric S
Abstract excerpt
Enhancers regulate gene expression through the binding of sequence-specific transcription factors (TFs) to cognate motifs. Various features influence TF binding and enhancer function-including the chromatin state of the genomic locus, the affinities of the binding site, the activity of the bound TFs, and interactions among TFs. However, the precise nature and relative contributions of these features remain...
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