Article

Low nucleus to cytoplasmic ratio compromises cytokinesis, genome stability and development in haploid embryonic cells

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian species exist as diploid organisms, with only gametes existing as stable, nonproliferating haploids. Haploid mammalian pluripotent stem cells, in all derived species to date - mouse, human and rat - undergo spontaneous diploidization. Here, we investigated the mechanisms affecting the stability of the haploid state using the mouse and human embryo, as well as a human embryonic stem cel...

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Identifiers and source

Literature Corpus work: e9038e07-edde-5bad-b35f-e981a1049131
DOI: 10.1101/2025.08.30.673237

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