Article

Genetic instability from a single S-phase after whole genome duplication

2021-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Diploid and stable karyotypes are associated with health and fitness in animals. In contrast, whole genome duplications (WGDs) - doubling full chromosome content - are linked to genetic instability (GIN) and frequently found in human cancers 1–3 . It has been established that WGDs fuel chromosome instability through abnormal mitosis 4–8 , however, the immediate consequences of tetraploidy in t...

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Literature Corpus work: ba2cf146-70ab-5e9e-a0c1-252bd7f8294f
DOI: 10.1101/2021.07.16.452672

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