Article
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk.
Nature genetics - 1 Jun 2022
Turner Adam W, Hu Shengen Shawn, Mosquera Jose Verdezoto, Ma Wei Feng, Hodonsky Chani J, Wong Doris, Auguste Gaëlle, Song Yipei, Sol-Church Katia, Farber Emily, Kundu Soumya, Kundaje Anshul, Lopez Nicolas G, Ma Lijiang, Ghosh Saikat Kumar B, Onengut-Gumuscu Suna, Ashley Euan A, Quertermous Thomas, Finn Aloke V, Leeper Nicholas J, Kovacic Jason C, Björkegren Johan L M, Zang Chongzhi, Miller Clint L
Abstract excerpt
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have identified over 200 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis-regulatory elements. Here, we applied single-nucleus assay for transposase-accessible chromatin with sequencing to profile 28,316 nuclei...
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