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Dynamic neuroinflammatory profiles predict Alzheimer’s disease pathology in microglia-containing cerebral organoids

2023-11-16

Abstract excerpt

Neuroinflammation and the underlying dysregulated immune responses of microglia actively contribute to the progression and, likely, the initiation of Alzheimer’s disease (AD). Fine-tuned therapeutic modulation of immune dysfunction to ameliorate disease cannot be achieved without the characterization of diverse microglial states that initiate unique, and sometimes contradictory, immune responses that evolve over t...

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Literature Corpus work
50f17bc8-4a4a-5ef2-8f51-5ecbb747b675
DOI
10.1101/2023.11.16.567220
Open publication

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Dynamic neuroinflammatory profiles predict Alzheimer’s disease pathology in microglia-containing cerebral organoidsDOI 10.1101/2023.11.16.567220
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