Article

Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the <i>MAPT</i> -S305N model of frontotemporal dementia

2026-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Progressive and chronic neuroinflammation is associated with numerous neurodegenerative diseases, including primary tauopathies such as frontotemporal dementia and progressive supranuclear palsy. Unlike Alzheimer’s disease, there is no clear genetic association implicating microglial dysfunction as a primary driver of tauopathy. As such, the contributions of microglia to tauopathy pathogenesis h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a78d376a-b1cc-524a-958f-c39585570bee
DOI: 10.64898/2026.06.30.735652

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the <i>MAPT</i> -S305N model of frontotemporal dementiaDOI 10.64898/2026.06.30.735652Read

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau.Semantic proximity Read

Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaSemantic proximity Read

New Human IPSC Models of Late-onset Alzheimer’s Disease Polygenic Risk Identify Multiple Impairments of Microglial FunctionSemantic proximity Read

iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory PhenotypeSemantic proximity Read

Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microgliaSemantic proximity Read

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding PotencySemantic proximity Read

iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype.Semantic proximity Read

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity Read

Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell TechnologiesSemantic proximity Read

ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progressionSemantic proximity Read

Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets.Semantic proximity Read

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence RiskSemantic proximity Read