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Article

iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype.

Journal of neuroinflammation - 4 Jan 2024

Sullivan Michael A, Lane Samuel D, McKenzie André D J, Ball Sarah R, Sunde Margaret, Neely G Gregory, Moreno Cesar L, Maximova Alexandra, Werry Eryn L, Kassiou Michael

Abstract excerpt

BACKGROUND: Widescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer's disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic states encompassing cytokine/chemokine release, phagocytosis and morphological profiles, but to date studies are limited to cells derived from PSEN1, APOE and APP mutations or sporadic patients. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38178159
DOI: 10.1186/s12974-023-02951-2
PMCID: PMC10765839

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