Article

Allelic expression analysis of Imprinted and X-linked genes from bulk and single-cell transcriptomes

2020-05-23

Abstract excerpt

Genomic imprinting and X chromosome inactivation (XCI) are two prototypical epigenetic mechanisms whereby a set of genes is expressed mono-allelically in order to fine-tune their expression levels. Defects in genomic imprinting have been observed in several neurodevelopmental disorders, in a wide range of tumours and in induced pluripotent stem cells (iPSCs). Single Nucleotide Variants (SNVs) are readily detectabl...

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Literature Corpus work: bab481ca-cc14-5923-a757-93158ea2a707
DOI: 10.1101/2020.05.20.105841

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