Article

IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions

2020-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Genomic imprinting is an epigenetic phenomenon leading to parental allele-specific expression. Dosage of imprinted genes is crucial for normal development and its dysregulation accounts for several human disorders. This unusual expression pattern is mostly dictated by differences in DNA methylation between parental alleles at specific regulatory elements known as imprinting control regions (ICRs...

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Literature Corpus work: 37128bcc-0c56-5154-b838-6a92a7975452
DOI: 10.1101/2020.03.21.000042

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