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Article

ASPEN: Robust detection of allelic dynamics in single cell RNA-seq.

PLoS computational biology - 1 Dec 2025

Petrova Veronika, Niu Muqing, Vierbuchen Thomas S, Wong Emily S

Abstract excerpt

Single-cell RNA-seq data from F1 hybrids provide a unique framework for dissecting complex regulatory mechanisms, but allelic measurements are limited by technical noise due to low counts. Here, we present ASPEN, a statistical method for modeling allelic mean and variance in single-cell transcriptomic data. ASPEN combines a sensitive mapping pipeline with a moderated beta-binomial model and adaptive shrinkage to...

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Identifiers

PMID: 41417871
DOI: 10.1371/journal.pcbi.1013837
PMCID: PMC12774380

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