Article
Successful computational prediction of novel imprinted genes from epigenomic features.
Molecular and cellular biology - 1 Jul 2010
Brideau Chelsea M, Eilertson Kirsten E, Hagarman James A, Bustamante Carlos D, Soloway Paul D
Abstract excerpt
Approximately 100 mouse genes undergo genomic imprinting, whereby one of the two parental alleles is epigenetically silenced. Imprinted genes influence processes including development, X chromosome inactivation, obesity, schizophrenia, and diabetes, motivating the identification of all imprinted loci. Local sequence features have been used to predict candidate imprinted genes, but rigorous testing using...
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