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BrewerIX enables allelic expression analysis of imprinted and X-linked genes from bulk and single-cell transcriptomes.

Communications biology - 17 Feb 2022

Martini Paolo, Sales Gabriele, Diamante Linda, Perrera Valentina, Colantuono Chiara, Riccardo Sara, Cacchiarelli Davide, Romualdi Chiara, Martello Graziano

Abstract excerpt

Genomic imprinting and X chromosome inactivation (XCI) are two prototypical epigenetic mechanisms whereby a set of genes is expressed mono-allelically in order to fine-tune their expression levels. Defects in genomic imprinting have been observed in several neurodevelopmental disorders, in a wide range of tumours and in induced pluripotent stem cells (iPSCs). Single Nucleotide Variants (SNVs) are readily...

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Identifiers

PMID: 35177756
DOI: 10.1038/s42003-022-03087-4
PMCID: PMC8854590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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