Article
Mechanisms generating cancer genome complexity from a single cell division error.
Science (New York, N.Y.) - 17 Apr 2020
Umbreit Neil T, Zhang Cheng-Zhong, Lynch Luke D, Blaine Logan J, Cheng Anna M, Tourdot Richard, Sun Lili, Almubarak Hannah F, Judge Kim, Mitchell Thomas J, Spektor Alexander, Pellman David
Abstract excerpt
The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can be observed in cancer genomes alongside chromothripsis, another catastrophic mutational phenomenon. We explain this association by elucidating a mutational cascade that is triggered by a single cell division error-chromosome bridge formation-that rapidly...
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