Article

Cell Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells

2019-03-20

Abstract excerpt

Polyploidy arises from the gain of complete chromosomes sets [1] and is known to promote cancer genome evolution. Recent evidence suggests that a large proportion of human tumours experience whole genome duplications (WGDs), which might favour the generation of highly abnormal karyotypes within a short time frame, rather than in a stepwise manner [2–6]. However, the molecular mechanisms linking whole genome duplic...

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Literature Corpus work: a4943c3a-e114-5da0-9bb6-4677a7b5777a
DOI: 10.1101/582460

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