Article

A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation

2025-02-03

Abstract excerpt

Unscheduled whole genome duplication (WGD), also described as unscheduled or non-physiological polyploidy, can lead to genetic instability and is commonly observed in human cancers. WGD generates DNA damage due to scaling defects between replication factors and DNA content. As a result, DNA damage repair mechanisms are thought to be critical for ensuring cell viability and proliferation under these conditions. In...

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Literature Corpus work: 6cf35c55-2122-58e9-a3b0-75d486f22ae6
DOI: 10.1101/2025.02.03.636185

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