Article

Whole genome duplication through mitotic slippage causes nuclear instability

2025-07-21

Abstract excerpt

Whole-genome duplication (WGD), leading to polyploidy can arise in physiological and pathological contexts 1–5 . WGD can occur via non-canonical cell cycles such as mitotic slippage, cytokinesis failure or endoreplication 1,3 . Whether the routes to WGD influence the behaviour of the resulting polyploid cells remains unclear. Here, we compared these routes under both physiological and non-physiological condition...

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Literature Corpus work: 4018b7a0-3359-56cf-8cdd-ad3f8ffc5911
DOI: 10.1101/2025.07.21.665898

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