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Whole-Genome Doubling as a source of cancer: how, when, where, and why?

5 Jun 2023

Abstract excerpt

Chromosome instability is a well-known hallmark of cancer, leading to increased genetic plasticity of tumoral cells, which favors cancer aggressiveness, and poor prognosis. One of the main sources of chromosomal instability are events that lead to a Whole-Genome Duplication (WGD) and the subsequently generated cell polyploidy. In recent years, several studies showed that WGD occurs at the early stages of cell...

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PMID: 37342233
DOI: 10.3389/fcell.2023.1209136

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