Article

Mitosis without DNA replication in mammalian somatic cells

2020-07-09

Abstract excerpt

<h4>SUMMARY</h4> DNA replication initiates with pre-replication complex (pre-RC) formation at replication origins in G1 (replication origin licensing), followed by activation of a pre-RC subset in the S phase. It has been suggested that a checkpoint prevents S phase entry when too few origins are licensed. Yet, we found that in normal cells, complete DNA synthesis inhibition by overexpression of a non-degradable...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f3a6e0f-f541-51c8-b9eb-7e33ddeb2f16
DOI: 10.1101/2020.07.08.193607

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitosis without DNA replication in mammalian somatic cellsDOI 10.1101/2020.07.08.193607Read

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read

Rescue from replication stress during mitosisSemantic proximity Read

Genetic instability from a single S-phase after whole genome duplicationSemantic proximity Read

Distinct and sequential re-replication barriers ensure precise genome duplicationSemantic proximity Read

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cellsSemantic proximity Read

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cellsSemantic proximity Read

Tripolar mitosis in human cells and embryos: Occurrence, pathophysiology and medical implicationsSemantic proximity Read

“The Octet”: Eight Protein Kinases that Control Mammalian DNA ReplicationSemantic proximity Read

Delayed DNA replication in haploid human embryonic stem cellsSemantic proximity Read

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Semantic proximity Read

Pathways for maintenance of telomeres and common fragile sites during DNA replication stressSemantic proximity Read