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Profiling cell proliferation after whole-genome duplication in human cells

2026-03-13

Abstract excerpt

Though whole-genome duplication (WGD) contributes to cancer progression, the mechanism of post-WGD cell proliferation remains unclear. Here, using 6-day live-imaging, we analyzed the proliferation dynamics of more than 150 post-WGD HCT116 cell lineages. A quantitative comparison of mitotic patterns and cell fates between proliferative and non-proliferative lineages revealed that multipolar chromosome segregation i...

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Literature Corpus work
380ab396-61e8-5fa9-b394-66ba2db96619
DOI
10.64898/2026.03.12.711482
Open publication

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Profiling cell proliferation after whole-genome duplication in human cellsDOI 10.64898/2026.03.12.711482
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