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Pathways for maintenance of telomeres and common fragile sites during DNA replication stress

1 Apr 2018

Abstract excerpt

Oncogene activation during tumour development leads to changes in the DNA replication programme that enhance DNA replication stress. Certain regions of the human genome, such as common fragile sites and telomeres, are particularly sensitive to DNA replication stress due to their inherently 'difficult-to-replicate' nature. Indeed, it appears that these regions sometimes fail to complete DNA replication within the...

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PMID: 29695617
DOI: 10.1098/rsob.180018

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