Article

Optical genome mapping identifies source-associated structural variant differences across early-passage human iPSCs

2026-05-31

Abstract excerpt

<h4>Background</h4> Induced pluripotent stem cells (iPSCs) are an important model for studying human diseases in vitro . However, previous studies have shown that iPSC reprogramming and extended cell culture can introduce genomic structural variants (SVs). Technologies like karyotyping, CNV microarrays, and whole-genome sequencing have limitations in resolution, sensitivity, or the ability to detect large and co...

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Literature Corpus work: 32d8a0ba-9e15-58cd-89fc-9beaa14c6944
DOI: 10.64898/2026.05.29.728843

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