Prenatal Life is the Predominant Source of Somatic Mosaicism Across Tissues and Aging

Abstract excerpt

<title>Abstract</title> <p>Despite the well-known rise in somatic mutations with age, their true impact on aging—and the origins of mosaicism—has remained elusive. Here we present a powerful new framework that reconstructs the timing of somatic mutations across the entire lifespan using only adult tissues, integrating single-cell transcriptomics with high-resolution variant calling. Applying this framework to hum...

Topics

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• Aging
• Genome-Wide Association Study
• High-Throughput Nucleotide Sequencing
• Models, Genetic
• Mosaicism
• Mutation
• Neoplasms
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

e1da0ec3-4032-59eb-bdf6-029a1db26ecb

DOI

10.21203/rs.3.rs-8663812/v1