Article

Temporal stability of human sperm mosaic mutations results in life-long threat of transmission to offspring

2020-10-14

Abstract excerpt

<h4>Summary</h4> Every newborn harbors scores of new single nucleotide variants (SNVs) that may impact health and disease 1–4 ; the majority of these are contributed by the paternal germ cells 5 . In some cases, these mutations are identifiable in a subset of the parents’ cells—a phenomenon called mosaicism, which is capable of producing disease recurrence 6–8 . Here, we provide a comprehensive analysis of mal...

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Literature Corpus work: 835b0168-6d3e-5372-855f-2053215e6b49
DOI: 10.1101/2020.10.14.339796

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