Article
The Somatic Mosaicism across Human Tissues Network.
Nature - 1 Jul 2025
Coorens Tim H H, Oh Ji Won, Choi Yujin Angelina, Lim Nam Seop, Zhao Boxun, Voshall Adam, Abyzov Alexej, Antonacci-Fulton Lucinda, Aparicio Samuel, Ardlie Kristin G, Bell Thomas J, Bennett James T, Bernstein Bradley E, Blanchard Thomas G, Boyle Alan P, Buenrostro Jason D, Burns Kathleen H, Chen Fei, Chen Rui, Choudhury Sangita, Doddapaneni Harsha V, Eichler Evan E, Evrony Gilad D, Faith Melissa A, Fazzio Thomas G, Fulton Robert S, Garber Manuel, Gehlenborg Nils, Germer Soren, Getz Gad, Gibbs Richard A, Hernandez Raquel G, Jin Fulai, Korbel Jan O, Landau Dan A, Lawson Heather A, Lennon Niall J, Li Heng, Li Yan, Loh Po-Ru, Marth Gabor, McConnell Michael J, Mills Ryan E, Montgomery Stephen B, Natarajan Pradeep, Park Peter J, Satija Rahul, Sedlazeck Fritz J, Shao Diane D, Shen Hui, Stergachis Andrew B, Underhill Hunter R, Urban Alexander E, VonDran Melissa W, Walsh Christopher A, Wang Ting, Wu Tao P, Zong Chenghang, Lee Eunjung Alice, Vaccarino Flora M
Abstract excerpt
From fertilization onwards, the cells of the human body acquire variations in their DNA sequence, known as somatic mutations. These postzygotic mutations arise from intrinsic errors in DNA replication and repair, as well as from exposure to mutagens. Somatic mutations have been implicated in some diseases, but a fundamental understanding of the frequency, type and patterns of mutations across healthy human...
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