Article

Multi-organ analysis of low-level somatic mosaicism reveals stage- and tissue-specific mutational features in human development

2021-08-24

Abstract excerpt

Most somatic mutations arising during normal development present as low-level in single or multiple tissues depending on the developmental stage and affected organs 1-4 . However, it remains unclear how the human developmental stages or mutation-carrying organs affect somatic mutations’ features. Here, we performed a systemic and comprehensive analysis of low-level somatic mutations using deep whole-exome sequenc...

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Literature Corpus work: fe313145-d0d8-52e4-b93a-7a13aa04b49e
DOI: 10.1101/2021.08.23.457440

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