Article

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes

2025-06-16

Abstract excerpt

Schizophrenia is a complex neuropsychiatric disorder with strong genetic underpinnings, yet the molecular mechanisms linking genetic risk to disrupted brain development remain poorly understood. Transcription factors (TFs) and chromatin regulators (CRs) are increasingly implicated in neuropsychiatric disorders, where their dysregulation may disrupt neurodevelopmental programs. Despite this, systematic functional i...

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Literature Corpus work: 8dec2940-3cdb-5429-a8d5-d6a6cf8ad05f
DOI: 10.1101/2025.06.13.659629

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