Article

Cis-Regulatory Hubs: a new 3D Model of Complex Disease Genetics with an Application to Schizophrenia

2021-06-22

Abstract excerpt

The 3-dimensional (3D) conformation of the chromatin creates complex networks of noncoding regulatory regions (distal elements) and promoters impacting gene regulation. Despite the importance of the role of noncoding regions in complex diseases, little is known about their interplay within regulatory hubs and implication in multigenic diseases like schizophrenia. Here we show that cis-regulatory hubs (CRHs) in neu...

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Literature Corpus work: 13e56cf4-9297-5224-ad28-4f076462b209
DOI: 10.1101/2021.06.22.449467

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