Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

3D genetic architecture of schizophrenia risk across three neuronal subtypes.

Molecular psychiatry - 1 Apr 2026

Powell Samuel K, Liao Will, Ghorbani Sadaf, Rigat Raymond, O'Shea Callan, Kammourh Sarah, Elahi Rahat, Infante Dana, Deans P J Michael, Le Derek J, Agarwal Poonam, Qiang Seow Wei, Balafkan Novin, Wang Kevin C, Akbarian Schahram, Brennand Kristen J

Abstract excerpt

Common genetic variants associated with schizophrenia risk are concentrated in non-coding regulatory sequences, but their precise target genes are context-dependent and impacted by cell-type-specific three-dimensional spatial chromatin organization. Here, we map long-range chromosomal conformations in human dopaminergic, GABAergic, and glutamatergic neurons to track developmentally programmed shifts in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GABAergic Neurons

Share to Genetic Predisposition to Disease

Share to Neurons

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 41310180
DOI: 10.1038/s41380-025-03352-y
PMCID: PMC12999511

Genes

BHLHE22
SNAP91

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

3D genetic architecture of schizophrenia risk across three neuronal subtypes.PMID 41310180Read ↗

Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal SubtypesSemantic proximity Read ↗

The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal developmentSemantic proximity Read ↗

Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disordersSemantic proximity Read ↗

The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal developmentSemantic proximity Read ↗

Cis-Regulatory Hubs: a new 3D Model of Complex Disease Genetics with an Application to SchizophreniaSemantic proximity Read ↗

Chromosome conformation elucidates regulatory relationships in developing human brain.Semantic proximity Read ↗

Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia.Semantic proximity Read ↗

Acetylated Chromatin Domains Link Chromosomal Organization to Cell- and Circuit-level Dysfunction in Schizophrenia and Bipolar DisorderSemantic proximity Read ↗

Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampusSemantic proximity Read ↗

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.Semantic proximity Read ↗

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.Semantic proximity Read ↗

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.