Article
Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.
Cell stem cell - 7 Sept 2017
Forrest Marc P, Zhang Hanwen, Moy Winton, McGowan Heather, Leites Catherine, Dionisio Leonardo E, Xu Zihui, Shi Jianxin, Sanders Alan R, Greenleaf William J, Cowan Chad A, Pang Zhiping P, Gejman Pablo V, Penzes Peter, Duan Jubao
Abstract excerpt
Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding sequences. To investigate, we mapped global OCRs in neurons differentiating from hiPSCs, a cellular model for studying...
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