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CRISPR-engineered deletion of <i>POGZ</i> alters transcription factor binding at promoters of genes involved in synaptic signaling

2025-10-27

Abstract excerpt

<h4>ABSTRACT</h4> One of the seminal discoveries from genetic studies of autism spectrum disorder and related neurodevelopmental disorders (NDD) has been that loss-of-function (LoF) mutations in many genes that impact chromatin and transcriptional regulation confer substantial liability to NDD. Haploinsufficiency of the epigenetic regulator POGZ represents one of the strongest such associations; however, little...

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Literature Corpus work
fd33eca4-c1ca-5274-80aa-dd2c06ae5f8e
DOI
10.1101/2025.10.27.684870
Open publication

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CRISPR-engineered deletion of <i>POGZ</i> alters transcription factor binding at promoters of genes involved in synaptic signalingDOI 10.1101/2025.10.27.684870
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