Article

Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

2022-10-08

Abstract excerpt

The human frontal cortex and hippocampus play critical roles in learning and cognition. We investigated the epigenomic and 3D chromatin conformational reorganization during the development of the frontal cortex and hippocampus, using more than 53,000 joint single-nucleus profiles of chromatin conformation and DNA methylation (sn-m3C-seq). The remodeling of DNA methylation predominantly occurs during late-gestation...

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Literature Corpus work: b34442fd-142c-5256-8e09-866cfee5f039
DOI: 10.1101/2022.10.07.511350

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