Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.

Nature communications - 6 Apr 2026

Singh Swadha, Iskhakova Marina, Lambert Tova Y, Valada Aditi, Shokrian Neda, Evans Viviana, Bendl Jaroslav, Auluck Pavan K, Marenco Stefano, Wang Minghui, Zhang Bin, Hoffman Gabriel E, Girdhar Kiran, Roussos Panos, Akbarian Schahram

Abstract excerpt

Ventral midbrain dopaminergic neurons are a key cell type for schizophrenia pathophysiology but information about cell type-specific genomic dysregulation in diseased brains is missing. We generated a unique midbrain functional genomics resource with 97 RNA-seq and 34 Hi-C chromosomal contact libraries for Nurr1 + /NeuN+ dopaminergic and their surrounding Nurr1-/NeuN- nuclei, collected from donors diagnosed with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Genetic Predisposition to Disease

Share to Mesencephalon

Share to Nuclear Receptor Subfamily 4, Group A, Member 2

Share to Schizophrenia

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 41942462
DOI: 10.1038/s41467-026-71281-7
PMCID: PMC13234368

Genes

FOXP1
MAPK10
NRXN1
PCM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.PMID 41942462Read ↗

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.Semantic proximity Read ↗

A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neuronsSemantic proximity Read ↗

3D genetic architecture of schizophrenia risk across three neuronal subtypes.Semantic proximity Read ↗

The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal developmentSemantic proximity Read ↗

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilienceSemantic proximity Read ↗

Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal SubtypesSemantic proximity Read ↗

The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal developmentSemantic proximity Read ↗

Single-cell multi-cohort dissection of the schizophrenia transcriptomeSemantic proximity Read ↗

Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Identifies Novel Risk Genes for Schizophrenia.Semantic proximity Read ↗

Gene Expression Elucidates Functional Impact of Polygenic Risk for SchizophreniaSemantic proximity Read ↗

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.Semantic proximity Read ↗

Contrasting genetic predisposition and diagnosis in psychiatric disorders: a multi-omic single-nucleus analysis of the human orbitofrontal cortexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.