Article

Tuberculosis resistance protein TOLLIP controls immune pathology by resolving the integrated stress response in alveolar macrophages.

2022-02-23

Abstract excerpt

<title>Abstract</title> A functional polymorphism responsible for TOLLIP deficiency is associated with increased tuberculosis risk. However, TOLLIP’s role in TB pathogenesis is unknown. We found that <italic>Tollip</italic><italic>−/−</italic> mice develop severe <italic>Mycobacterium tuberculosis</italic> (Mtb) disease, characterized by lipid-laden foamy macrophages. This phenotype was intrinsic to...

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Literature Corpus work: b8571566-7159-5e7f-933d-778c2905f213
DOI: 10.21203/rs.3.rs-1363035/v1

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