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TREM2 <sup>+</sup> macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growth

2025-07-18

Abstract excerpt

Pulmonary tuberculosis (TB) exhibits marked spatial heterogeneity, with alveolar pneumonia and organized granulomas frequently coexisting within the same lung. While granulomas have long dominated conceptual models of TB pathogenesis, the immune programs operating within alveolar TB pneumonia in humans remain incompletely defined. Here, we integrate spatial transcriptomics, single-cell RNA sequencing, high-resolut...

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Literature Corpus work
9ac7ffaa-97bb-5336-a1fe-ccd6d877210d
DOI
10.1101/2025.07.15.664002
Open publication

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TREM2 <sup>+</sup> macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growthDOI 10.1101/2025.07.15.664002
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