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Article

Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2012

Shah Javeed A, Vary Jay C, Chau Tran T H, Bang Nguyen D, Yen Nguyen T B, Farrar Jeremy J, Dunstan Sarah J, Hawn Thomas R

Abstract excerpt

Tuberculosis, one of the leading causes of death worldwide, stimulates inflammatory responses with beneficial and pathologic consequences. The regulation and nature of an optimal inflammatory response to Mycobacterium tuberculosis remains poorly understood in humans. Insight into mechanisms of negative regulation of the TLR-mediated innate immune response to M. tuberculosis could provide significant breakthroughs...

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Share to Enzyme-Linked Immunosorbent Assay
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22778396
DOI: 10.4049/jimmunol.1103541
PMCID: PMC3428135

Genes

TOLLIP
TLR2
TLR4
TNF

Provenance

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