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Article

Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle

24 Nov 2020

Abstract excerpt

Abstract TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic-reticulum stress, an activator of autophagy, or a critical regulator of intracellular vacuole trafficking. The distinct functions of this protein have been linked to innate immune...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 33233920
DOI: 10.1165/rcmb.2020-0470tr

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