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TOLLIP resolves lipid-induced EIF2 signaling in alveolar macrophages for durable <i>Mycobacterium tuberculosis</i> protection

2020-08-24

Abstract excerpt

Relative deficiency of TOLLIP expression in monocytes is associated with increased tuberculosis (TB) susceptibility in genetic studies, despite antagonizing host innate immune pathways that control Mycobacterium tuberculosis (Mtb) infection. In this study, we investigated the mechanisms by which TOLLIP influences Mtb immunity. Tollip -/- mice developed worsened disease, consistent with prior genetic observations...

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Literature Corpus work
28a1e85e-9f94-560e-b354-3dc99f1f5a34
DOI
10.1101/2020.08.24.263624
Open publication

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TOLLIP resolves lipid-induced EIF2 signaling in alveolar macrophages for durable <i>Mycobacterium tuberculosis</i> protectionDOI 10.1101/2020.08.24.263624
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