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The PPE2 protein of <i>Mycobacterium tuberculosis</i> is responsible for the development of hyperglycemia and insulin resistance during tuberculosis

2025-08-13

Abstract excerpt

Diabetes is a known risk factor for tuberculosis (TB), but clinical evidences suggest that TB itself can induce hyperglycaemia and insulin resistance, though the underlying mycobacterial factors are not known. Herein, we implicate PPE2, a secretory PE/PPE family protein of Mycobacterium tuberculosis (Mtb), as a key modulator of adipose tissue physiology that contributes to the development of insulin resistance. I...

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Literature Corpus work
8ce2bbd5-e59a-5df1-8e6f-2cd506ead1a1
DOI
10.1101/2025.08.13.670014
Open publication

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The PPE2 protein of <i>Mycobacterium tuberculosis</i> is responsible for the development of hyperglycemia and insulin resistance during tuberculosisDOI 10.1101/2025.08.13.670014
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