Article

Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic stem cells

2020-09-10

Abstract excerpt

<h4>Summary</h4> When human cord blood derived CD34+ cells are induced to differentiate in vitro , they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment. Using ATAC-seq and single-cell RNA sequencing, we detected two phases in this process. In the first phase, we observed a rapid and global chromatin opening that makes most of the gene promoters in the g...

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Literature Corpus work: b85699bf-0f61-55b5-8d2b-0834afaffcf2
DOI: 10.1101/2020.09.09.289751

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