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Article

Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment

27 Jul 2017

Abstract excerpt

Individual cells take lineage commitment decisions in a way that is not necessarily uniform. We address this issue by characterising transcriptional changes in cord blood-derived CD34+ cells at the single-cell level and integrating data with cell division history and morphological changes determined by time-lapse microscopy. We show that major transcriptional changes leading to a multilineage-primed gene...

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Share to Hematopoietic Stem Cell Transplantation
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PMID: 28749943
DOI: 10.1371/journal.pbio.2001867

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