Article

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution

2021-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs. In this study, we used single cell RNA sequencing (scRNAseq) to characterize an enriched population of human hematopoietic stem and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: febb90d8-5e5e-520c-b79b-2737d794a00e
DOI: 10.1101/2021.07.30.454542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolutionDOI 10.1101/2021.07.30.454542Read

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolutionSemantic proximity Read

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cellsSemantic proximity Read

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human developmentSemantic proximity Read

Architectural fragility of gene regulatory networks underlies hematopoietic stem cell agingSemantic proximity Read

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic HierarchySemantic proximity Read

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study.Semantic proximity Read

EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)Semantic proximity Read

Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiencySemantic proximity Read

Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiationSemantic proximity Read

Hematopoiesis at single cell resolution spanning human development and maturationSemantic proximity Read

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to LeukemiaSemantic proximity Read

Mapping Human Hematopoietic Hierarchy at Single Cell Resolution by Microwell-seqSemantic proximity Read