Article

Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment

2017-01-18

Abstract excerpt

Individual cells take lineage commitment decisions in a way that is not necessarily uniform. We address this issue by characterizing transcriptional changes in cord blood derived CD34+ cells at the single-cell level and integrating data with cell division history and morphological changes determined by time-lapse microscopy. We show, that major transcriptional changes leading to a multilineage-primed gene expressi...

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Literature Corpus work: cc6ad74b-e855-5093-b688-e96a47f0ce0b
DOI: 10.1101/101428

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