Article

Robust temporal map of human <i>in vitro</i> myelopoiesis using single-cell genomics

2021-11-19

Abstract excerpt

<h4>Summary</h4> Myeloid cells have a central role in homeostasis and tissue defence. Characterising the current in vitro protocols of myelopoiesis is imperative for their use in research and immunotherapy as well as for understanding the early stages of myeloid differentiation in humans. Here, we profiled the transcriptome of more than 400k cells and generated a robust molecular map of the differentiation of hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a28ad428-3033-5cb5-accd-4f5b9ae11286
DOI: 10.1101/2021.11.17.469005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust temporal map of human <i>in vitro</i> myelopoiesis using single-cell genomicsDOI 10.1101/2021.11.17.469005Read

An integrated analysis of myeloid cells identifies gaps in <i>in vitro</i> models of <i>in vivo</i> biologySemantic proximity Read

Decoding the development of the blood and immune systems during human fetal liver haematopoiesisSemantic proximity Read

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cellsSemantic proximity Read

An integrated analysis of human myeloid cells identifies gaps in in vitro models of in vivo biology.Semantic proximity Read

Multimodal analysis of <i>in vitro</i> hematopoiesis reveals blood cell-specific genetic impacts on complex disease traitsSemantic proximity Read

Single cell transcriptome analysis reveals markers of naïve and lineage-primed hematopoietic progenitors derived from human pluripotent stem cellsSemantic proximity Read

The Aorta-Gonad-Mesonephros niche shapes the functions of yolk sac-derived macrophages involved in hematopoietic stem and progenitor cell generation <i>ex vivo</i>Semantic proximity Read

Hematopoiesis at single cell resolution spanning human development and maturationSemantic proximity Read

Deciphering the differentiation trajectory from hematopoietic stem cells to mast cellsSemantic proximity Read

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human developmentSemantic proximity Read

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activationSemantic proximity Read

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis.Semantic proximity Read