Article

Actin nucleators safeguard replication forks by limiting nascent strand degradation

2023-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication forks. These responses rely on the formation of Replication Protein A (RPA)-single stranded (ss) DNA complexes, yet this process remains largely uncharacterized. Here we establish that actin nucleation-p...

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Literature Corpus work: 8d067b74-1183-53fe-90ca-dedcad0b0d85
DOI: 10.1101/2023.01.12.523639

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