Article

Extended DNA binding interface beyond the canonical SAP domain contributes to SDE2 function at DNA replication forks

2022-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Elevated DNA replication stress causes instability of the DNA replication fork and DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator SDE2 binds to TIMELESS (TIM) of the fork protection complex (FPC) and enhances its stability, thereby supporting replisome activity at DNA replication forks. Here, we structurally and functionally characterize a new conserved DNA bi...

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Literature Corpus work: d6324ed8-4971-5b30-a409-50b42140b59d
DOI: 10.1101/2022.05.09.490802

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