Article

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinks

2025-07-29

Abstract excerpt

Replication stress is a major driver of genomic instability and is implicated in the development of diseases such as cancer. It triggers the S-phase checkpoint, a signaling pathway that coordinates the handling of replication obstacles with cell cycle progression. One prominent source of replication stress is the formation of DNA-protein crosslinks on the template, such as those induced by DNA topoisomerase I pois...

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Literature Corpus work: 35e1c736-e857-518f-8558-15f0c37dbae4
DOI: 10.1101/2025.07.28.667195

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