Article

Acute multi-level response to defective de novo chromatin assembly in S-phase

2024-03-25

Abstract excerpt

Long-term perturbation of de novo chromatin assembly during DNA replication has profound effects on epigenome maintenance and cell fate. The early mechanistic origin of these defects is unknown. Here, we combine acute degradation of Chromatin Assembly Factor 1 (CAF-1), a key player in de novo chromatin assembly, with single-cell genomics, quantitative proteomics, and live-microscopy to uncover these initiating mec...

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Literature Corpus work: 9c10ab6b-0c4f-5781-bf20-10bd63e77e82
DOI: 10.1101/2024.03.22.586291

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