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Rescue from replication stress during mitosis

6 Feb 2017

Abstract excerpt

Genomic instability is a hallmark of cancer and a common feature of human disorders, characterized by growth defects, neurodegeneration, cancer predisposition, and aging. Recent evidence has shown that DNA replication stress is a major driver of genomic instability and tumorigenesis. Cells can undergo mitosis with under-replicated DNA or unresolved DNA structures, and specific pathways are dedicated to resolving...

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PMID: 28166452
DOI: 10.1080/15384101.2017.1288322

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