Article

Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating

2024-11-04

Abstract excerpt

Voltage-gated sodium channels (VGSCs), key mediators of excitability and synaptic transmission, are established and functionally relevant targets for volatile anaesthetic (VA) action. Using the structurally homologous prokaryotic VGSCs NavMs and NaChBac as models, we present a structure-function analysis of VGSC-VA interactions. We report that multiple VAs compete for binding sites on NavMs, and that these direct...

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Literature Corpus work: b82c38e0-e84c-563d-9907-5fbe117296a9
DOI: 10.1101/2024.11.04.621342

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